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Exercise capacity is a predictor of cardiovascular events in patients with type 2 diabetes mellitus

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, US

Raymond O Estacio

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, US

Paulos Berhanu

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, US

Robert W. Schrier

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, US

Peak exercise oxygen consumption (peak VO₂), as measured by expired gas analysis, is an accurate, reproducible and reliable method for determining exercise capacity. In this study, a cohort of 468 patients with type 2 diabetes underwent graded exercise testing to measure peak VO₂ at baseline; the cohort was followed for five years for the occurrence of cardiovascular disease (CVD) events. Patients who developed CVD events during the five-year follow-up period were found to have significantly lower baseline peak VO₂, as compared to those who did not (p=0.02). Analysis by gender showed that the mean peak VO₂ in male patients who developed CVD events was significantly lower than the peak VO₂ in those who did not (p<0.03). Multiple Cox regression analysis also showed low peak VO₂ to be an independent factor.

In conclusion, patients with type 2 diabetes mellitus with reduced peak VO₂ during exercise have a greater tendency to develop future CVD events.

Key Words: exercise • peak VO2 • diabetes mellitus • cardiovascular events

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Diabetes and Vascular Disease Research, Vol. 3, No. 3, 197-201 (2006)
DOI: 10.3132/dvdr.2006.030


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